Ministerio de Ciencia e Innovación

Bipolar Disorder

Bipolar disorder affects over 2% of the population and has a serious impact on lives of those who suffer from this mental illness. CIBERSAM's research programme on this illness is one of the world leaders in the identification of the causes and treatment of bipolar disorder and it is making a substantial contribution to improving its prognosis, both through pharmacotherapy and innovative psychological interventions. CIBERSAM's research has made possible to identify risk genes, brain circuits involved in emotional dysregulation, biomarkers and psychosocial triggers involved in the onset of the disorder which, in the future, with the necessary financial support, will bring us ever closer to the goal of curing and effectively preventing the disease.

Lines of research

  • Determination of prevalence, incidence, comorbidity and disability associated with bipolar disorder.
  • Study of bipolar patients in early stages of their illness and the genetic and environmental factors associated with the staging of the illness.
  • Analysis of the role of neurocognition and neuroimaging as an endophenotype and as a potentially treatable prognostic factor.
  • Validation of psychometric instruments for use in bipolar disorder.
  • Research into biomarkers, drugs and psychosocial interventions to improve the treatment of bipolar disorder.


Coordinator: Vicent Balanzá Martínez. Universidad de Valencia. Facultad de Medicina. C. Valenciana.

Main ResearcherConsortium InstitutionRegionsDetails
José Luis Ayuso Mateos Hospital Universitario La Princesa Madrid View group
Pilar Alejandra Sáiz Martínez Universidad de Oviedo. Facultad de Medicina Asturias View group
Ana González-Pinto Arrillaga Hospital Universitario de Álava País Vasco View group
Edith Pomarol Clotet Fundación para la Investigacion y Docencia Maria Angustias Gimenez (FIDMAG) C. Valenciana View group
Rafael Tabares Seisdedos Universidad de Valencia. Facultad de Medicina C. Valenciana View group
Eduard Vieta Pascual Hospital Clinico y Provincial de Barcelona Cataluña View group
Elisabet Vilella Cuadrada Fundación Instituto de Investigación Sanitaria Pere Virgili Cataluña View group