Bipolar Disorder

Bipolar disorder affects over 2% of the population and has a serious impact on the lives of those who suffer from this. The CIBERSAM programme for research into this illness is one of the world leaders in identification of the causes and treatment of bipolar disorder. It is making a substantial contribution to improving its prognosis, both through pharmacotherapy and through innovative psychological interventions. The research done by the CIBERSAM has allowed us to identify the risk genes, cerebral circuits involved in emotional dysregulation, biomarkers and the psychosocial triggering factors involved in the appearance of this disorder, which will in the future, with the required economic support, enable us to get increasingly closer to the objective of curing and effectively preventing the illness.

Lines of research

  • Determining the prevalence, incidence, comorbidity and incapacity associated with bipolar disorder.
  • Study of bipolar patients in early phases of their illness and the genetic and environmental factors associated with its stadiage.
  • Analysis of the role of neurocognition and neuroimaging as endophenotype and as a potentially treatable prognostic factor.
  • Validation of psychometric instruments for use in bipolar disorder.
  • Research into biomarkers, drugs and psychosocial interventions to improve the treatment of bipolar disorder.


Main ResearcherConsortium InstitutionRegionsDetails
Peter J. Mckenna Hospital Hermanas Hospitalarias Benito Menni Cataluña View group
Eduard Vieta Pascual Hospital Clinico y Provincial de Barcelona Cataluña View group
Rafael Tabares Seisdedos Universidad de Valencia. Facultad de Medicina C. Valenciana View group
Ana González-Pinto Arrillaga Hospital Universitario de Álava País Vasco View group
Julio Bobes García Universidad de Oviedo. Facultad de Medicina Asturias View group
José Luis Ayuso Mateos Hospital Universitario La Princesa Madrid View group